El haloperidol durante dos meses reapareci la corea cual resolvi pidamente reinstaurar tratamiento. Request PDF on ResearchGate Chor de Sydenham chez . Sydenham se graduó de la Universidad de Oxford en y obtuvo el título de del láudano de opio y de la corteza del árbol de chinchona en el tratamiento de logros están el descubrimiento de la Corea de Sydenham, también conocida. eficacia de carbamazepina, haloperidol y acido valproico en el tratamiento de niños con corea de Sydenham: seguimiento clínico de 18 pacientes’ in DOAJ.

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The onset of symptoms preceded the hospital admission ranging from 1 to 30 days in 15 patients, and in more than 30 days in 9 cases. Received 21 Septemberreceived in final form 7 December Laboratory tests included hemogram, liver function, antistreptolysin O and streptozyme titers, erythrocyte sedimentation, reactive C-protein, LE cells, antinuclear antibodies, complement, anticardiolipin antibodies; electrocardiography, electroencephalography and neuroimaging.

The symptoms recorded in the remaining 18 cases were classified as mild, moderate or severe according to the criteria established by Aron et al. A small comparison study randomized 18 SC patients to treatment with either carbamazepine, tratamientk acid, or haloperidol. El haloperidol durante dos meses reapareci la corea cual resolvi pidamente reinstaurar sydenha.

Risperidone is mentioned as a failed treatment in a study focusing on plasmapheresis discussed below. An impressive list of therapeutic options has been used to treat this disorder: Acta Physiol Oxf ; An Esp Pediatr ; A single case report suggested improvement of symptoms in fe patients with SC because of the administration of vitamin E 50 IU administered daily for 2 weeks. The patients were divided in three equal groups, and sdenham given a standardized dose of each of the drugs built-up over a week.

The typical age of onset of SC is 5—15 years fe females are more affected than males. Randomized double-blind study with prednisone in Sydenham’s chorea. Curr Op Neurol Neurosurg ;4: Solo tres de los pacientes que recibieron haloperidol mejoraron.


In view of the present results we sydenahm valproic acid as the first choice drug to treat Sydenham chorea. A dose of 0. Neuroimaging revealed no abnormalities.


Three patients developed mitral valve insufficiency. Separate online searches were conducted using PubMed, Embase, Psychinfo, and clinicaltrials. In another recent trial that compared HP and sodium valproate in a series of 24 patients, the percentage of individuals that responded to treatment was significantly higher in the HP group In a similar study performed in Jerusalem, 10 out of 19 SC patients seven females zydenham a total of 11 recurrences of chorea.

Steroids have been used as first-choice therapy in chorea paralytica, although there is also a single case report of successful treatment using valproic acid. Effectiveness of sodium valproate in the treatment of Sydenham’s chorea.

The variability in the results of the serologic tests may occur as a consequence of differences among the streptococcal strains, or they may be secondary to the presence of other precipitants 21, The available literature supports a beneficial response to haloperidol; however, it is the neuroleptic most reported to cause unacceptable side effects. Author information Article notes Copyright and License information Disclaimer. The duration of treatment is dependent on the severity of cardiac involvement.

Clinical, laboratory, psychiatric and magnetic resonance findings in patients with Sydenham chorea. Therapeutic improvement was reported in 4 days in one out of four patients; improvement time for the others was not clearly specified. Campen R, Mufio Vero G. Of the immunomodulatory therapies investigated, steroids have the strongest supporting evidence, but side effects are not uncommon.

Treatment of Sydenham’s Chorea: A Review of the Current Evidence

Patient selection was based on the following criteria: Penicillin prophylaxis appears to reduce the likelihood of further cardiac complications and the recurrence rate of chorea. Nevertheless, we believe that it should be reserved for patients with sydenhm paralytica or for those with disabling symptoms who fail, or cannot tolerate, symptomatic treatment.


Levetiracetam Efficacy in a Child. Beneficial use of immunoglobulins in the treatment of Sydenham chorea. Further complicating therapeutic syxenham is the fact that the sole placebo-controlled study reported improvement of chorea after 2 weeks of placebo treatment.

Harries-Jones and Gibson Data from these studies were incorporated into our total number, recognizing that negative case reports usually go unpublished and the deficiency of placebo-controlled trials. Alvarez LA, Novak G.

Thus, it is unclear whether this sensitivity is unique re SC or reflects a gender difference. These reappearances of chorea were not predictable by either prior rheumatic fever activity or cardiac findings. Although there is a theoretical basis for IVIG and plasmapheresis and it appears to have at least equal efficacy in a single small comparison study, we hesitate to recommend these approaches before a trial with steroids.

For example, reports varied on whether they provided the time to improvement of symptoms 10 out of 44192527dw35 — 384255 the time to full remission of symptoms two out of 442128 or both 13 out of It has been suggested that patients with SC may be particularly vulnerable to extrapyramidal side effects.

Concerns for this study include lack of placebo control arm, use of a non-validated rating scale, and failure of the blinded observer to perform the initial evaluation at the beginning of the protocol. American Society for Microbiology, The methodologies used to assess clinical symptoms and outcomes in the reviewed references varied widely. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

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Tierney MR, Kaplan S. Only three of the patients that received haloperidol improved. Am J Med ;